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2 Etiology: 1,2,4 Drugs most implicated in the etiology of DRESS: Aromatic Anti-epileptic Drugs: carbamazepine (most common), phenytoin, phenobarbital, lamotrigine Allopurinol (2 nd most common) Sulfonamides: Trimethoprim- Sulfamethoxazole (TMP-SMX), dapsone, sulfasalazine Minocycline Vancomycin Pathogenesis not fully understood: Theorized predominantly due to genetic mutations in drug detoxification enzymes leading to accumulation of toxic metabolites

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Adding to its beauty, the dress is embellished with intricate appliques and includes a stylish slit, providing a modern twist to the classic A-Line design